Dr. İlyas Şahin Medical Oncologist

Dr. İlyas Şahin Medical Oncologist

Dr. Ilyas Sahin is a medical oncologist based in Boston in the United States, serving at Massachusetts General Hospital, one of the world’s leading hospitals, and a faculty member (Assistant Professor) at Harvard Medical School.

In his clinical practice he focuses especially on liver, stomach, esophageal and pancreatic cancers, while his research covers all solid tumors (including lung, breast, prostate, colorectal and other cancers), working on next-generation cancer drugs and early-phase clinical trials.

  • Assistant Professor of Medicine, Harvard Medical School
  • Termeer Center for Targeted Therapies and Center for GI Cancers, MGH
  • US board certification in internal medicine, hematology, and medical oncology
  • Graduate of Hacettepe University Faculty of Medicine; sees patients in Turkish and English
  • Kanserle Savaşta Kontrol Sizde (in Turkish) — author

Kanserle Savaşta Kontrol Sizde

A book answering the most-asked and most commonly misunderstood questions about cancer with scientific evidence.

All questions

The book and its answers are presented in Turkish.

Research

Plain-language summaries of studies published in peer-reviewed journals. Each summary links to the original article.

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Original article: Mechanisms of drug resistance in HCC. Hepatology, 2024

Why does liver cancer become resistant to drugs?

A comprehensive review bringing together the mechanisms that cause treatments to lose their effectiveness over time in hepatocellular carcinoma, and the approaches being developed to overcome this resistance.

ReviewCo-author427 citations
Open the original article

Original abstract: Clinical validation of Northstar Response, a novel methylated ctDNA therapy response monitoring assay. ASCO GI, 2024

Can treatment response be tracked with a blood test?

Initial results of a new test that measures tumor-derived DNA fragments in the blood to monitor whether treatment is working in advanced gastrointestinal cancers.

Clinical researchFirst author
Open the original abstract

Clinical Notes

Short notes and literature interpretations Dr. Sahin shares on X, translated into English. Each note includes the underlying source and a link to the original post.

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Liver
Could AI help radiologists catch liver cancers that might otherwise be missed? An AI system that analyzes liver CT scans was tested prospectively in 10,333 consecutive patients. The system flagged 51 previously missed lesions, 15 of which were cancer. Ultimately 37 radiology reports were revised and 22 patients were referred for multidisciplinary evaluation. A single-center study whose findings still require radiologist confirmation, but a meaningful step toward real clinical use.
Source: Nature MedicineRead more →
Event
It was wonderful to discuss the opportunities and challenges in precision oncology on the #WINSympo2026 panel today. Thanks to the WIN Consortium for bringing together such a strong group!
Source: WIN Sempozyumu 2026Read more →
Immunotherapy
A pooled analysis of 1,038 patients with operable melanoma who received treatment before surgery. Among the 735 patients who received immunotherapy, 58% had very little or no viable tumor left at the time of surgery. About 98% of these patients were alive at 5 years.
Source: Nature MedicineRead more →

Scientific publications

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2.900+

citations, Google Scholar (October 2026)

  • Ladd AD, Duarte S, Sahin I, Zarrinpar A. Mechanisms of drug resistance in HCC. Hepatology, 2024.
  • Palaz F, Ozsoz M, Zarrinpar A, Sahin I. CRISPR in targeted therapy and adoptive T cell immunotherapy for hepatocellular carcinoma. Journal of Hepatocellular Carcinoma, 2024.

Career

  1. 2003–2011
    Hacettepe Üniversitesi Tıp Fakültesi
    Doctor of Medicine (MD)
  2. 2012–2014
    Dana-Farber Cancer Institute / Harvard Medical School
    Postdoctoral researcher; multiple myeloma and the tumor microenvironment
  3. 2014–2015
    Montefiore Medical Center / Albert Einstein College of Medicine
    Internal medicine internship
  4. 2015–2017
    Mount Auburn Hospital
    Internal medicine residency
  5. 2017–2020
    Brown University / Rhode Island Hospital
    Hematology and medical oncology fellowship; research on 3D tissue engineering models
  6. 2020–2021
    Warren Alpert Medical School, Brown University
    Assistant Professor of Medicine; Lifespan Cancer Institute
  7. 2021–2024
    University of Florida, UF Health Cancer Center
    Assistant Professor, division of hematology and oncology
  8. Ağustos 2024–
    Massachusetts General Hospital, Harvard Medical School
    Medical oncologist and Phase 1 oncologist; Termeer Center and Center for GI Cancers