Plain-language summaries of studies published in peer-reviewed journals. Each summary links to the original article.
Original article: Mechanisms of drug resistance in HCC. Hepatology, 2024
A comprehensive review bringing together the mechanisms that cause treatments to lose their effectiveness over time in hepatocellular carcinoma, and the approaches being developed to overcome this resistance.
Open the original articleOriginal abstract: Clinical validation of Northstar Response, a novel methylated ctDNA therapy response monitoring assay. ASCO GI, 2024
Initial results of a new test that measures tumor-derived DNA fragments in the blood to monitor whether treatment is working in advanced gastrointestinal cancers.
Open the original abstractOriginal article: CRISPR in Targeted Therapy and Adoptive T Cell Immunotherapy for Hepatocellular Carcinoma. J Hepatocell Carcinoma, 2024
A review of how CRISPR technology could be used in targeted therapies and in treatments that use the patient’s own T cells.
Open the original articleOriginal article: Effects of Clinical and Tumor Characteristics on Survival in Patients with Hepatocellular Carcinoma with Bone Metastasis.
A study examining the association between clinical and tumor characteristics and survival in patients with hepatocellular carcinoma and bone metastasis.
Open the original articleOriginal article: Adoptive cell therapy in hepatocellular carcinoma: a review of clinical trials. Cancers, 2023
A review summarizing the clinical trials of treatments in which immune cells are strengthened in the laboratory and returned to the patient, in liver cancer.
Find on Google ScholarOriginal article: Durable pembrolizumab response in metastatic MSS ARID1A-mutant undifferentiated carcinoma of the esophagus. J Chemother, 2025
A case report describing a long-lasting response in a patient who was not expected to benefit from immunotherapy because of a genetic feature.
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